Inflammation and activity augment brain-derived neurotrophic factor peripheral release
نویسندگان
چکیده
منابع مشابه
Chemical Alterations – Peripheral Brain-derived Neurotrophic Factor
Brain-derived neurotrophic factor (BDNF) is a neurotrophin that regulates neuronal survival and growth during development. Effects of BDNF on neuronal transmission in the hippocampus, cortex, cerebellum and basal forebrain are important for learning and memory processes [1]. Reduced BDNF may affect synaptic efficiency and connectivity in schizophrenia that is hypothesized to underpin signs and ...
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Cytokines are key regulatory mediators involved in the host response to immunological challenges, but also play a critical role in the communication between the immune and the central nervous system. For this, their expression in both systems is under a tight regulatory control. However, pathological conditions may lead to an overproduction of pro-inflammatory cytokines that may have a detrimen...
متن کاملBrain-derived neurotrophic factor:
Dekan Summary BDNF (brain-derived neurotrophic factor) plays an important role in neuronal survival, growth and maintenance of several neuronal systems, serves as neurotransmitter modulator and participates in plasticity important for learning and memory. BDNF is widely expressed in the CNS, beginning early in development and extending throughout life. In the mammalian brain, it is most abundan...
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Brain-derived neurotrophic factor (BDNF) is known to play a role in experience-dependent plasticity of the developing visual cortex. For example, BDNF acutely enhances long-term potentiation and blocks long-term depression in the visual cortex of young rats. Such acute actions of BDNF suggested to be mediated mainly through presynaptic mechanisms. A chronic application of BDNF to the visual cor...
متن کاملAction of brain-derived neurotrophic factor on function and morphology of visual cortical neurons
Brain-derived neurotrophic factor (BDNF) is known to play a role in experience-dependent plasticity of the developing visual cortex. For example, BDNF acutely enhances long-term potentiation and blocks long-term depression in the visual cortex of young rats. Such acute actions of BDNF suggested to be mediated mainly through presynaptic mechanisms. A chronic application of BDNF to the visual cor...
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ژورنال
عنوان ژورنال: Neuroscience
سال: 2016
ISSN: 0306-4522
DOI: 10.1016/j.neuroscience.2016.01.018